Experience-dependent homeostatic synaptic plasticity in neocortex

Experience-dependent homeostatic synaptic plasticity in neocortex.

The organism's ability to adapt to the changing sensory environment is due in part to the ability of the nervous system to change with experience. Input and synapse specific Hebbian plasticity, such as long-term potentiation (LTP) and long-term depression (LTD), are critical for sculpting the nervous system to wire its circuit in tune with the environment and for storing memories. However, thes...

MSK1 regulates homeostatic and experience-dependent synaptic plasticity.

The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response to environmental influences, the cellular and molecular mechanisms underlying synaptic adaptation are far from clear. Brain-derived neurotrophic...

Homeostatic Synaptic Plasticity

Homeostatic synaptic plasticity mechanisms provide a means for neurons and circuits to maintain stable function in the face of perturbations such as developmental or activitydependent changes in synapse number or strength. These forms of plasticity use negative feedback signaling to adjust synaptic properties to keep activity close to some internal set point value. Recent work suggests that the...

Nonglobal homeostatic synaptic plasticity?

BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex

Alzheimer's disease (AD) is the most common form of age-related dementia, which is thought to result from overproduction and/or reduced clearance of amyloid-beta (Aβ) peptides. Studies over the past few decades suggest that Aβ is produced in an activity-dependent manner and has physiological relevance to normal brain functions. Similarly, physiological functions for β- and γ-secretases, the two...